Protein atf4
Webb16 juli 2024 · ATF4 belongs to the basic-region leucine zipper (bZIP) family of transcription factors and functions as heterodimers with other bZIP proteins, such as c-Fos, c-Jun, or CCAAT/enhancer-binding... WebbATF4. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.
Protein atf4
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WebbATF4 expression can be regulated at transcriptional, translational, and post-translational levels. The functional activation of ATF4 under hypoxia and the overexpression of ATF4 … WebbExpression of ATF4 in cancer - Summary - The Human Protein Atlas ATF4 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC …
WebbMitochondrial stress stimulates OMA1-dependent cleavage of DELE1 and leads to the accumulation of DELE1 in the cytosol, where it interacts with HRI and activates the eIF2α kinase activity of HRI. In addition, DELE1 is required for ATF4 translation downstream of eIF2α phosphorylation. Blockade of the OMA1-DELE1-HRI pathway triggers an ... Webb12 apr. 2024 · Mammals respond to amino acid (AA) deficiency by initiating an AA response pathway (AAR) that involves the activation of general control nonderepressible …
Webb30 aug. 2013 · We determined the effect of ATF4 on hepatic lipid metabolism in Atf4 (-/-) mice fed regular chow or provided with free access to fructose drinking water. ATF4 … Webb1 mars 2024 · ATF4 is a metabolic effector of mTORC1 signaling, co-opted to induce gene targets involved in amino acid synthesis, uptake, and tRNA charging, contributing to mTORC1-driven protein and glutathione synthesis.
Webbför 8 timmar sedan · They found that Aβ42 caused 2 proteins — ATF4 and CREB3L2 — to bind together. The pairing of these 2 proteins is linked to about half of the gene expression changes that happen in brain cells ...
WebbThe inhibition of EGFR or PI3K mutant proteins, pharmacologically or through genetic knockdown, inhibited ATF4 induction without affecting GCN2 activation. A downstream analysis revealed that the oncogenic EGFR-PI3K pathway may utilize mTOR-mediated translation control mechanisms for ATF4 induction. probability geometric distributionWebb25 juni 2013 · ATF4 is a master regulator that plays a crucial role in the adaptation to stresses by regulating the transcription of many genes ( 3 , 10–12 ). ATF4 triggers increased transcription by binding to C/EBP-ATF Response Element (CARE) sequences of a subset of specific target genes ( 13–15 ). probability general formulaWebbSearch: ATF4 - The Human Protein Atlas More information. Don't show this again. SECTIONS TISSUE BRAIN SINGLE CELL TYPE TISSUE CELL TYPE PATHOLOGY DISEASE … probability genetics definitionTwo alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. ATF4 transcription factor is also known to play role in osteoblast differentiation along with RUNX2 and osterix. Visa mer Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene. Visa mer This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in … Visa mer • Activating transcription factor Visa mer • ATF4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Human ATF4 genome location and Visa mer The translation of ATF4 is dependent on upstream open reading frames located in the 5'UTR. The location of the second uORF, aptly named … Visa mer • Rutkowski DT, Kaufman RJ (April 2003). "All roads lead to ATF4". Developmental Cell. 4 (4): 442–4. doi:10.1016/S1534-5807(03)00100-X. PMID 12689582. • Nishizawa M, Nagata … Visa mer probability geometryWebb19 nov. 2015 · Activating transcription factor 4 (ATF4) is a basic region-leucine zipper transcription factor that is widely expressed in many tissues and cells and functions as a stress response factor and a developmental regulator. 10 The absence of ATF4 induces partial perinatal lethality 11 and results in severe anemia and abnormal erythropoiesis in … probability geometry definitionWebbATF4 is a basic leucine zipper (bZIP) stress-responsive transcription factor that belongs to the CREB/ATF family of transcription factors that are able to homodimerize or heterodimerize to regulate gene expression (Rzymski et al., 2009; Wortel et al., 2024 ). probability generating function propertiesWebbDuring ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 … probability getting royal flush