WebCast nephropathy is due to the interaction and aggregation of filtered free light chains (FLCs) and Tamm- Horsfall protein (THP) causing intratubular obstruction and damage. … Web29 mar. 2024 · Acute kidney injury (AKI) caused by light chain cast nephropathy (LCCN) is one of the major complications from multiple myeloma (MM). It is most commonly seen at initial MM diagnosis but can also develop later in the course of disease during relapse.
Clinically Suspected Cast Nephropathy: A Retrospective, Multi-Center ...
Web18 iul. 2013 · Renal insufficiency is associated with high morbidity and mortality in multiple myeloma. One of the common causes for acute renal failure in multiple myeloma is cast nephropathy. It is important to reduce the levels of light chains to improve renal failure and also the overall outcome. Web7 dec. 2024 · Cast nephropathy is the most form of kidney disease in patients with multiple myeloma and it can be associated with worse prognosis. To this date, the role … thelatc
Pulmonary Hypertension Complicating Multiple Myeloma
WebZurück zum Zitat Cook M, Hutchison C, Fifer L (2016) HCO-HD does not improve outcomes in myeloma cast nephropathy: results of European trial of free light chain removal extended haemodialysis in cast nephropathy. European Hematology Association, 9–12 June 2016. abstract P270 Cook M, Hutchison C, Fifer L (2016) HCO-HD does not … Web13 mai 2024 · The term “Cast nephropathy” (CN) relates to a pathological feature mostly seen in myeloma kidney, but also present to a lesser degree in the context of severe nephrotic syndrome (NS) by whatever cause. In many renal biopsies from patients with a monoclonal (MC) serum component, heavy proteinuria or the NS, distal convoluted … Web23 iun. 2024 · Acute kidney injury (AKI) due to myeloma cast nephropathy requires urgent intervention to achieve rapid renal recovery, which is a crucial prognostic factor. Renal response is conditioned by drastic reduction of nephrotoxic serum free light chains. This requires efficient but tolerable antiplasma cell chemotherapy, which has never been ... the laszlo project